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Title: Physicochemical and blood compatibility characterization of polypyrrole surface functionalized with heparin
Authors: Li, Y.
Neoh, K.G. 
Cen, L. 
Kang, E.-T. 
Keywords: Electrical stimulation
Plasma recalcification time
Platelet adhesion
Surface modification
Issue Date: 5-Nov-2003
Citation: Li, Y., Neoh, K.G., Cen, L., Kang, E.-T. (2003-11-05). Physicochemical and blood compatibility characterization of polypyrrole surface functionalized with heparin. Biotechnology and Bioengineering 84 (3) : 305-313. ScholarBank@NUS Repository.
Abstract: A surface modification technique was developed for the covalent immobilization of heparin onto electrically conductive polypyrrole (PPY) film. The PPY film was first graft copolymerized with poly(ethylene glycol) methacrylate (PEGMA) and then activated with cyanuric chloride (CC). Heparin was then immobilized onto the film through the reaction between the chloride groups of CC and the amine and/or hydroxyl groups of heparin. X-ray photoelectron spectroscopy (XPS) was used to characterize the surface-modified film after each stage. The biocompatibility of the surface-modified PPY was evaluated using plasma recalcification time (PRT) and platelet adhesion. After surface modification, the film had improved wettability while retaining significant electrical conductivity. With immobilized heparin, platelet adhesion and platelet activation on PPY film was significantly suppressed, and the PRT was significantly prolonged. Electrical stimulation also plays a positive role in decreasing platelet adhesion and increasing PRT on pristine and surface-modified PPY films. © 2003 Wiley Periodicals, Inc.
Source Title: Biotechnology and Bioengineering
ISSN: 00063592
DOI: 10.1002/bit.10757
Appears in Collections:Staff Publications

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