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|Title:||Optimization of the reversed-phase high-performance, liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column|
|Authors:||Velmurugan, T. |
Column liquid chromatography
|Citation:||Velmurugan, T.,Ching, C.B.,Ng, S.C.,Bai, Z.W.,Ong, T.T. (2002). Optimization of the reversed-phase high-performance, liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column. Chromatographia 56 (3-4) : 229-232. ScholarBank@NUS Repository.|
|Abstract:||Heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin has been synthesized and chemically immobilized on silica gel for use as a chiral stationary phase (PC-CSP) for analytical separation of the enantiomers of chiral drugs. Separation of the enantiomers of tolperisone was studied by high-performance liquid chromatography under reversed-phase conditions. The chromatographic conditions were optimized by varying mobile phase pH, composition, ionic strength, and velocity; 40:60 methanol-1% triethylammonium acetate (TEAA) buffer, pH 5.5, was found to be the most suitable for this separation.|
|Appears in Collections:||Staff Publications|
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