Please use this identifier to cite or link to this item:
|Title:||Computational fluid dynamics simulation of the adsorption separation of three components in high performance liquid chromatography|
|Keywords:||Column liquid chromatography|
Computational fluid dynamics
|Source:||Wu, Y.X.,Wang, X.,Ching, C.B. (2002). Computational fluid dynamics simulation of the adsorption separation of three components in high performance liquid chromatography. Chromatographia 55 (7-8) : 439-445. ScholarBank@NUS Repository.|
|Abstract:||The four stereoisomers of nadolol were successfully separated into three groups (SRS)-nadolol and (SSR)-nadolol, (RRS)-nadolol and (RSR)-nadolol using HPLC. The adsorption equilibrium coefficients, mass transfer coefficients of the three groups and the bed voidage were experimentally determined. The computational fluid dynamics (CFD) simulation of the separation was carried out using FEMLAB, which is application software from MATLAB. The simulation visualized the processes of dispersion and separation occurring inside the column. The curvature of the concentration profiles within the column were observed using the simulation. The simulated chromatogram correctly predicted the peak behavior of the eluted compounds except dispersion was overestimated, which is due to the limitation of the software used.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 7, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.