Please use this identifier to cite or link to this item: https://doi.org/10.1142/S0217984904006779
Title: Kinetic analysis of protein folding lattice models
Authors: Chen, H. 
Zhou, X.
Chih, Y.L. 
Chan, G.K. 
Keywords: Chevron rollover
Go model
HP model
Monte Carlo simulation
Protein folding
Issue Date: 20-Feb-2004
Source: Chen, H., Zhou, X., Chih, Y.L., Chan, G.K. (2004-02-20). Kinetic analysis of protein folding lattice models. Modern Physics Letters B 18 (4) : 163-172. ScholarBank@NUS Repository. https://doi.org/10.1142/S0217984904006779
Abstract: Based on two-dimensional square lattice models of proteins, the relation between folding time and temperature is studied by Monte Carlo simulation. The results can be represented by a kinetic model with three states - random coil, molten globule, and native state. The folding process is composed of nonspecific collapse and final searching for the native state. At high temperature, it is easy to escape from local traps in the folding process. With decreasing temperature, because of the trapping in local traps, the final searching speed decreases. Then the folding shows chevron rollover. Through the analysis of the fitted parameters of the kinetic model, it is found that the main difference between the energy landscapes of the HP model and the Go model is that the number of local minima of the Go model is less than that of the HP model.
Source Title: Modern Physics Letters B
URI: http://scholarbank.nus.edu.sg/handle/10635/65741
ISSN: 02179849
DOI: 10.1142/S0217984904006779
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