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Title: Silica nanocapsules of fluorescent conjugated polymers and superparamagnetic nanocrystals for dual-mode cellular imaging
Authors: Tan, H. 
Wang, M.
Yang, C.-T.
Pant, S.
Bhakoo, K.K.
Wong, S.Y.
Chen, Z.-K.
Li, X.
Wang, J. 
Keywords: conjugated polymers
imaging agents
iron oxide
template synthesis
Issue Date: 6-Jun-2011
Source: Tan, H., Wang, M., Yang, C.-T., Pant, S., Bhakoo, K.K., Wong, S.Y., Chen, Z.-K., Li, X., Wang, J. (2011-06-06). Silica nanocapsules of fluorescent conjugated polymers and superparamagnetic nanocrystals for dual-mode cellular imaging. Chemistry - A European Journal 17 (24) : 6696-6706. ScholarBank@NUS Repository.
Abstract: We describe here a facile and benign synthetic strategy to integrate the fluorescent behavior of conjugated polymers and superparamagnetic properties of iron oxide nanocrystals into silica nanocapsules, forming a new type of bifunctional magnetic fluorescent silica nanocapsule (BMFSN). The resultant BMFSNs are uniform, colloidally stable in aqueous medium, and exhibit the desired dual functionality of fluorescence and superparamagnetism in a single entity. Four conjugated polymers with different emissions were used to demonstrate the versatility of employing this class of fluorescent materials for the preparation of BMFSNs. The applicability of BMFSNs in cellular imaging was studied by incubating them with human liver cancer cells, the result of which demonstrated that the cells could be visualized by dual-mode fluorescence and magnetic resonance imaging. Furthermore, the superparamagnetic behavior of the BMFSNs was exploited for in vitro magnetic-guided delivery of the nanocapsules into the cancer cells, thereby highlighting their potential for targeting biomedical applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Chemistry - A European Journal
ISSN: 09476539
DOI: 10.1002/chem.201003632
Appears in Collections:Staff Publications

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