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|Title:||PEOlated micelle/silica as dual-layer protection of quantum dots for stable and targeted bioimaging|
|Authors:||Zhang, Y. |
|Citation:||Zhang, Y., Wang, M., Zheng, Y.-G., Tan, H., Hsu, B.Y.-W., Yang, Z.-C., Wong, S.Y., Chang, A.Y.-C., Choolani, M., Li, X., Wang, J. (2013-08-13). PEOlated micelle/silica as dual-layer protection of quantum dots for stable and targeted bioimaging. Chemistry of Materials 25 (15) : 2976-2985. ScholarBank@NUS Repository.|
|Abstract:||CdSe/CdS/ZnS quantum dots (QDs) have been successfully encapsulated into poly(ethylene oxide) (PEO)-based polymeric micelle/silica dual layers via interfacial templating condensation. The encapsulation follows a green and straightforward microemulsion mechanism that directly proceeds in a near-neutral pH aqueous environment. No detriment to the optical properties of QDs is observed during encapsulation. The core-shell nanoparticles generated possess a polymeric micelle framework with a single QD encapsulated in the hydrophobic micellar core, an ultrathin (<5 nm in thickness) yet robust silica shell confined to the micellar core/corona interface and free PEO chains dangling on the surface. The free PEO chains effectively prevent nonspecific adsorption of biomolecules to the nanoparticles. Double shielding of polymeric micelle/silica shell remarkably improves the fluorescence resistance of QDs to strong acids and highly salted buffers. In vitro testing using MDA-MB-231 breast cancer cells demonstrates that these organic/inorganic dual layer-protected QDs conjugated with folate show noncytotoxicity and bright fluorescence cellular imaging with high target specificity. © 2013 American Chemical Society.|
|Source Title:||Chemistry of Materials|
|Appears in Collections:||Staff Publications|
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