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Title: Extracting elastic properties and prestress of a cell using atomic force microscopy
Authors: Zhang, C.Y.
Zhang, Y.W. 
Issue Date: Mar-2009
Citation: Zhang, C.Y., Zhang, Y.W. (2009-03). Extracting elastic properties and prestress of a cell using atomic force microscopy. Journal of Materials Research 24 (3) : 1167-1171. ScholarBank@NUS Repository.
Abstract: An analytical solution was derived for the indentation of a cell using atomic force microscopy. It was found that the contribution of the cell membrane to the overall indentation stiffness is dependent on the size of the indenter. When a small indenter [for example, an atomic force microscopy (AFM) tip] is used to probe the mechanical properties of cells, the cell membrane and its prestress were important in interpreting indentation data. The solution allows the partition of contributions from the membrane and the interior soft phase. The apparent elastic modulus of the cell and the prestress of the cell membrane can be extracted. In addition, the modulus of the cell membrane could be estimated from the extracted apparent modulus if the interior soft phase of the cell was known and vice versa. However, when a large indenter is used (for example, a microbead attached to the cantilever beam of the AFM), the contribution of the cell membrane is negligible. © 2009 Materials Research Society.
Source Title: Journal of Materials Research
ISSN: 08842914
DOI: 10.1557/jmr.2009.0121
Appears in Collections:Staff Publications

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