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|Title:||Tunable spatial heterogeneity in structure and composition within aqueous microfluidic droplets|
|Authors:||Hui Sophia Lee, S.|
Kun Yap, S.
Alan Hatton, T.
|Citation:||Hui Sophia Lee, S., Wang, P., Kun Yap, S., Alan Hatton, T., Khan, S.A. (2012-04-26). Tunable spatial heterogeneity in structure and composition within aqueous microfluidic droplets. Biomicrofluidics 6 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1063/1.3694841|
|Abstract:||In this paper, we demonstrate biphasic microfluidic droplets with broadly tunable internal structures, from simple near-equilibrium drop-in-drop morphologies to complex yet uniform non-equilibrium steady-state structures. The droplets contain an aqueous mixture of poly(ethylene glycol) (PEG) and dextran and are dispensed into an immiscible oil in a microfluidic T-junction device. Above a certain well-defined threshold droplet speed, the inner dextran-rich phase is "stirred" within the outer PEG-rich phase. The stirred polymer mixture is observed to exhibit a near continuum of speed and composition-dependent phase morphologies. There is increasing interest in the use of such aqueous two-phase systems in microfluidic devices for biomolecular applications in a variety of contexts. Our work presents a method to go beyond equilibrium phase morphologies in generating microfluidic "multiple" emulsions and at the same time raises the possibility of biochemical experimentation in benign yet complex biomimetic milieus. © 2012 American Institute of Physics.|
|Appears in Collections:||Staff Publications|
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