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|Title:||Supersaturation control in cooling polymorphic co-crystallization of caffeine and glutaric acid|
|Citation:||Yu, Z.Q., Chow, P.S., Tan, R.B.H., Ang, W.H. (2011-10-05). Supersaturation control in cooling polymorphic co-crystallization of caffeine and glutaric acid. Crystal Growth and Design 11 (10) : 4525-4532. ScholarBank@NUS Repository. https://doi.org/10.1021/cg200745q|
|Abstract:||A model polymorphic co-crystallization process for caffeine-glutaric acid from acetonitrile was monitored and controlled using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and particle vision measurement (PVM). A new method to calculate supersaturation for co-crystallization systems was proposed and used in this study. Results showed that feedback control of supersaturation was effective in eliminating the nucleation of the metastable Form I of co-crystal and also produced the largest particles with the lowest proportion of fines. © 2011 American Chemical Society.|
|Source Title:||Crystal Growth and Design|
|Appears in Collections:||Staff Publications|
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