Please use this identifier to cite or link to this item: https://doi.org/10.1021/cg200745q
Title: Supersaturation control in cooling polymorphic co-crystallization of caffeine and glutaric acid
Authors: Yu, Z.Q.
Chow, P.S.
Tan, R.B.H. 
Ang, W.H.
Issue Date: 5-Oct-2011
Source: Yu, Z.Q., Chow, P.S., Tan, R.B.H., Ang, W.H. (2011-10-05). Supersaturation control in cooling polymorphic co-crystallization of caffeine and glutaric acid. Crystal Growth and Design 11 (10) : 4525-4532. ScholarBank@NUS Repository. https://doi.org/10.1021/cg200745q
Abstract: A model polymorphic co-crystallization process for caffeine-glutaric acid from acetonitrile was monitored and controlled using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and particle vision measurement (PVM). A new method to calculate supersaturation for co-crystallization systems was proposed and used in this study. Results showed that feedback control of supersaturation was effective in eliminating the nucleation of the metastable Form I of co-crystal and also produced the largest particles with the lowest proportion of fines. © 2011 American Chemical Society.
Source Title: Crystal Growth and Design
URI: http://scholarbank.nus.edu.sg/handle/10635/64631
ISSN: 15287483
DOI: 10.1021/cg200745q
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