Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.31854
Title: Structural stability and bioapplicability assessment of hyaluronic acid-chitosan polyelectrolyte multilayers on titanium substrates
Authors: Chua, P.H.
Neoh, K.G. 
Shi, Z. 
Kang, E.T. 
Keywords: Antibacterial
Chitosan
Hyaluronic acid
Layer by layer
Osteoblast
Issue Date: 15-Dec-2008
Citation: Chua, P.H., Neoh, K.G., Shi, Z., Kang, E.T. (2008-12-15). Structural stability and bioapplicability assessment of hyaluronic acid-chitosan polyelectrolyte multilayers on titanium substrates. Journal of Biomedical Materials Research - Part A 87 (4) : 1061-1074. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.31854
Abstract: Since bacterial infections associated with implants remain a major cause of their failure, this study investigated the use of polyelectrolyte multilayers (PEMs) comprising hyaluronic acid (HA) and chitosan (CH) to confer antibacterial properties on titanium (Ti). HA and CH were deposited on Ti using the layer-by-layer deposition method. The antibacterial efficacy of the functionalized Ti substrates was assessed using Escherichia coli and Staphylococcus aureus. The number of adherent bacteria on Ti functionalized with HA and CH PEMs was up to an order of magnitude lower than that on the pristine Ti. The effects of chemical crosslinking of the PEMs on the structural stability and antibacterial efficacy were investigated. The chemical crosslinking of the PEMs imparts greater structural stability and preserves the antibacterial properties even after the prolonged immersion in phosphate-buffered saline. The cytotoxicity of the PEMs to osteoblasts was evaluated using the MTT assay. The results showed that the biocompatible and long-lasting antibacterial nature of the functionalized Ti substrates offers great potential for reducing implant-associated infections. © 2008 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
URI: http://scholarbank.nus.edu.sg/handle/10635/64622
ISSN: 15493296
DOI: 10.1002/jbm.a.31854
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

40
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

37
checked on Jun 27, 2018

Page view(s)

34
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.