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Title: Silver nanocube-enhanced far-red/near-infrared fluorescence of conjugated polyelectrolyte for cellular imaging
Authors: Liang, J.
Li, K.
Gurzadyan, G.G.
Lu, X. 
Liu, B. 
Issue Date: 7-Aug-2012
Source: Liang, J., Li, K., Gurzadyan, G.G., Lu, X., Liu, B. (2012-08-07). Silver nanocube-enhanced far-red/near-infrared fluorescence of conjugated polyelectrolyte for cellular imaging. Langmuir 28 (31) : 11302-11309. ScholarBank@NUS Repository.
Abstract: We present the study of silver nanocube (Ag NC)-enhanced fluorescence of a cationic conjugated polyelectrolyte (CPE) for far-red/near-infrared fluorescence cell imaging. Layer-by-layer self-assembly of polyelectrolytes on 78 nm Ag NCs is used to control CPE-metal distance and its effect on CPE fluorescence. The highest fluorescence enhancement factor (FEF) is obtained for Ag NCs with two bilayers, corresponding to a CPE-metal spacer thickness of ∼6 nm. At the optimal excitation wavelength, the FEF is 13.8 with respect to the control silica nanoparticles (NPs). The fluorescent NPs are further used for cellular imaging studies. The CPE-loaded Ag NCs with two bilayers exhibit excellent image contrast, superior to the control of CPE-silica NP at a similar uptake efficiency. The viability test indicates low cytotoxicity of the CPE-loaded Ag NCs, rendering them as promising cell imaging agents. © 2012 American Chemical Society.
Source Title: Langmuir
ISSN: 07437463
DOI: 10.1021/la302511e
Appears in Collections:Staff Publications

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