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Title: Robust bayesian estimation of kinetics for the polymorphic transformation of L-glutamic acid crystals
Authors: Hermanto, M.W.
Kee, N.C.
Tan, R.B.H. 
Chiu, M.-S. 
Braatz, R.D.
Keywords: Bayesian inference
Markov chain monte carlo
Pharmaceutical crystallization modeling
Issue Date: Dec-2008
Source: Hermanto, M.W., Kee, N.C., Tan, R.B.H., Chiu, M.-S., Braatz, R.D. (2008-12). Robust bayesian estimation of kinetics for the polymorphic transformation of L-glutamic acid crystals. AIChE Journal 54 (12) : 3248-3259. ScholarBank@NUS Repository.
Abstract: Polymorphism, in which there exist different crystal forms for the same chemical compound, is an important phenomenon in pharmaceutical manufacturing. In this article, a kinetic model for the crystallization of L-glutamic acid polymorphs is developed from experimental data. This model appears to he the first to include all of the transformation kinetic parameters including dependence on the temperature. The kinetic parameters are estimated by Bayesian inference from hatch data collected from two in situ measurements: ATR-FTIR spectroscopy is used to infer the solute concentration, and FRRM that provides crystal size information. Probability distributions of the estimated parameters in addition to their point estimates are obtained by Markov Chain Monte Carlo simulation. The kinetic model can be used to better understand the effects of operating conditions on crystal quality, and the probability distributions can be used to assess the accuracy of model predictions and incorporated into robust control Strategies for polymorphic crystallization. © 2008 American Institute of Chemical Engineers.
Source Title: AIChE Journal
ISSN: 00011541
DOI: 10.1002/aic.11623
Appears in Collections:Staff Publications

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