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Title: Resolving the longstanding riddle of pH-dependent outcome of glycine polymorphic nucleation
Authors: Han, G.
Thirunahari, S.
Shan Chow, P.
Tan, R.B.H. 
Issue Date: 14-Feb-2013
Source: Han, G.,Thirunahari, S.,Shan Chow, P.,Tan, R.B.H. (2013-02-14). Resolving the longstanding riddle of pH-dependent outcome of glycine polymorphic nucleation. CrystEngComm 15 (6) : 1218-1224. ScholarBank@NUS Repository.
Abstract: We have experimentally studied the nucleation of acidic and basic glycine aqueous solutions using in situ Raman spectroscopy and hence resolved the longstanding riddle of pH-dependent polymorphic outcome. We have found that typical inorganic acids and bases accelerate the nucleation rates of both α- and γ-glycine, with γ-glycine promoted to a greater extent hence formed preferentially over α-glycine. We hypothesize that glycine ions, readily formed in an acidic or basic environment, induce head-to-tail molecular ordering which structurally matches γ-glycine and primarily directs nucleation path from α-glycine to γ-glycine. © 2013 The Royal Society of Chemistry.
Source Title: CrystEngComm
ISSN: 14668033
DOI: 10.1039/c2ce26594j
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