Please use this identifier to cite or link to this item: https://doi.org/10.1177/0748730407299194
Title: Phase sensitivity analysis of circadian rhythm entrainment
Authors: Gunawan, R. 
Doyle III, F.J.
Keywords: Circadian rhythm
Entrainment
Phase angle
Robustness
Seasonal tracking
Sensitivity analysis
Systems biology
Issue Date: Apr-2007
Source: Gunawan, R., Doyle III, F.J. (2007-04). Phase sensitivity analysis of circadian rhythm entrainment. Journal of Biological Rhythms 22 (2) : 180-194. ScholarBank@NUS Repository. https://doi.org/10.1177/0748730407299194
Abstract: As a biological clock, circadian rhythms evolve to accomplish a stable (robust) entrainment to environmental cycles, of which light is the most obvious. The mechanism of photic entrainment is not known, but two models of entrainment have been proposed based on whether light has a continuous (parametric) or discrete (nonparametric) effect on the circadian pacemaker. A novel sensitivity analysis is developed to study the circadian entrainment in silico based on a limit cycle approach and applied to a model of Drosophila circadian rhythm. The comparative analyses of complete and skeleton photoperiods suggest a trade-off between the contribution of period modulation (parametric effect) and phase shift (nonparametric effect) in Drosophila circadian entrainment. The results also give suggestions for an experimental study to (in)validate the two models of entrainment. © 2007 Sage Publications.
Source Title: Journal of Biological Rhythms
URI: http://scholarbank.nus.edu.sg/handle/10635/64398
ISSN: 07487304
DOI: 10.1177/0748730407299194
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