Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3nr04243j
Title: Near-infrared fluorescence amplified organic nanoparticles with aggregation-induced emission characteristics for in vivo imaging
Authors: Geng, J.
Zhu, Z.
Qin, W.
Ma, L.
Hu, Y.
Gurzadyan, G.G.
Tang, B.Z.
Liu, B. 
Issue Date: 21-Jan-2014
Source: Geng, J., Zhu, Z., Qin, W., Ma, L., Hu, Y., Gurzadyan, G.G., Tang, B.Z., Liu, B. (2014-01-21). Near-infrared fluorescence amplified organic nanoparticles with aggregation-induced emission characteristics for in vivo imaging. Nanoscale 6 (2) : 939-945. ScholarBank@NUS Repository. https://doi.org/10.1039/c3nr04243j
Abstract: Near-infrared (NIR) fluorescence signals are highly desirable to achieve high resolution in biological imaging. To obtain NIR emission with high brightness, fluorescent nanoparticles (NPs) are synthesized by co-encapsulation of 2,3-bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenylamino)phenyl)fumaronitrile (TPETPAFN), a luminogen with aggregation-induced emission (AIE) characteristics, and a NIR fluorogen of silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775) using 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [methoxy(polyethylene glycol)-2000] as the encapsulation matrix. The good spectral overlap between the emission of TPETPAFN and the absorption of NIR775 leads to efficient energy transfer, resulting in a 47-fold enhancement of the NIR775 emission intensity upon excitation of TPETPAFN at 510 nm as compared to that upon direct excitation of NIR775 at 760 nm. The obtained fluorescent NPs show sharp NIR emission with a band width of 20 nm, a large Stokes shift of 275 nm, good photostability and low cytotoxicity. In vivo imaging study reveals that the synthesized NPs are able to provide high fluorescence contrast in live animals. The Förster resonance energy transfer strategy overcomes the intrinsic limitation of broad emission spectra for AIE NPs, which opens new opportunities to synthesize organic NPs with high brightness and narrow emission for potential applications in multiplex sensing and imaging. © 2013 The Royal Society of Chemistry.
Source Title: Nanoscale
URI: http://scholarbank.nus.edu.sg/handle/10635/64287
ISSN: 20403364
DOI: 10.1039/c3nr04243j
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

45
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

43
checked on Nov 20, 2017

Page view(s)

45
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.