Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tet.2010.06.039
Title: Highly chemo- and regio-selective hydroxylations of o- and m-substituted toluenes to benzyl alcohols with Cellulosimicrobium cellulans EB-8-4
Authors: Dai, S. 
Wu, J.
Wang, Z. 
Chen, Y. 
Li, Z. 
Keywords: Alkyl toluenes
Benzyl alcohols
Biotransformations
Enzyme catalysis
Hydroxylations
Issue Date: 21-Aug-2010
Source: Dai, S., Wu, J., Wang, Z., Chen, Y., Li, Z. (2010-08-21). Highly chemo- and regio-selective hydroxylations of o- and m-substituted toluenes to benzyl alcohols with Cellulosimicrobium cellulans EB-8-4. Tetrahedron 66 (34) : 6919-6923. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tet.2010.06.039
Abstract: Highly chemo- and regio-selective benzylic hydroxylations of o- and m-substituted toluenes were achieved with the easily available and easy-to-handle resting cells of Cellulosimicrobium cellulans EB-8-4 as biocatalysts, giving the corresponding benzyl alcohols as single product. Benzyl alcohols were obtained in 78-94% yield, demonstrating the first green, clean, and simple method for the preparation of benzyl alcohols via hydroxylations. Biotransformation of 4-methylbenzyl chloride with the same strain gave 4-methylbenzyl alcohol in 67-81% yield, suggesting a novel dehalogenation activity of the cells and providing a novel, green, and efficient method for the preparation of 4-methylbenzyl alcohol as well as the application potential in biodegradation of chlorine-containing aromatics. © 2010 Elsevier Ltd. All rights reserved.
Source Title: Tetrahedron
URI: http://scholarbank.nus.edu.sg/handle/10635/64022
ISSN: 00404020
DOI: 10.1016/j.tet.2010.06.039
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