Please use this identifier to cite or link to this item:
Title: Heparinized magnetic nanoparticles: In-vitro assessment for biomedical applications
Authors: Wuang, S.C. 
Neoh, K.G. 
Kang, E.-T. 
Pack, D.W.
Leckband, D.E.
Issue Date: 5-Sep-2006
Citation: Wuang, S.C., Neoh, K.G., Kang, E.-T., Pack, D.W., Leckband, D.E. (2006-09-05). Heparinized magnetic nanoparticles: In-vitro assessment for biomedical applications. Advanced Functional Materials 16 (13) : 1723-1730. ScholarBank@NUS Repository.
Abstract: Superparamagnetic magnetite nanoparticles are of great interest owing to their numerous existing and potential biomedical applications. In this study, superparamagnetic magnetite nanoparticles with average diameters of 6-8 nm have been prepared and surface-functionalized with poly(N-isopropylacrylamide) (poly(NIPAAM)) via a surface-initiated atom-transfer radical polymerization, followed by immobilization of heparin. The success of the various surface-functionalization steps has been ascertained using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The rate of internalization of the as-synthesized and surface-functionalized magnetite nanoparticles by mouse macrophage cells has been investigated. The nanoparticle internalization into the macrophages has been visualized using optical microscopy and quantified by inductively coupled plasma spectroscopy. The effectiveness of the heparinized nanoparticles in preventing thrombosis has been determined using the plasma recalcification time. The results indicate that the above-mentioned surface modifications of the magnetite nanoparticles are effective in delaying phagocytosis and preventing blood clotting in vitro. Such properties can be expected to enable their use in biomedical applications. © 2006 WILEY-VCH Verlag GmbH & Co.
Source Title: Advanced Functional Materials
ISSN: 1616301X
DOI: 10.1002/adfm.200500879
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Dec 6, 2018


checked on Nov 28, 2018

Page view(s)

checked on Dec 8, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.