Please use this identifier to cite or link to this item: https://doi.org/10.1080/10717540801952597
Title: Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers
Authors: Phanapavudhikul, P.
Shen, S.
Ng, W.K.
Tan, R.B.H. 
Keywords: Acrylate-Based Polymer
Drug Release
Magnetic Nanocomposite
Polymer-Coated
Target Delivery
Issue Date: Mar-2008
Source: Phanapavudhikul, P., Shen, S., Ng, W.K., Tan, R.B.H. (2008-03). Formulation of Fe3O4/acrylate co-polymer nanocomposites as potential drug carriers. Drug Delivery 15 (3) : 177-183. ScholarBank@NUS Repository. https://doi.org/10.1080/10717540801952597
Abstract: Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and freeze-thaw stability. Electrostatic interaction between negatively charged model drug aspirin and positively charged co-polymer plays the most important role in drug loading and in vitro release studies. Drug release exhibited a biphasic profile with an initial burst release followed by a prolonged slow release, which could be potentially useful for target and controlled drug delivery. Copyright © Informa Healthcare USA, Inc.
Source Title: Drug Delivery
URI: http://scholarbank.nus.edu.sg/handle/10635/63947
ISSN: 10717544
DOI: 10.1080/10717540801952597
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