Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2009.09.036
Title: Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel
Authors: Liu, Y.
Li, K.
Pan, J.
Liu, B. 
Feng, S.-S. 
Keywords: Cancer nanotechnology
Chemotherapeutic engineering
Nanomedicine
Receptor-mediated endocytosis (RME)
Surface conjugation
Taxanes
Issue Date: Jan-2010
Citation: Liu, Y., Li, K., Pan, J., Liu, B., Feng, S.-S. (2010-01). Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel. Biomaterials 31 (2) : 330-338. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2009.09.036
Abstract: A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer core was developed for targeted delivery of anticancer drugs with Docetaxel as a model drug, which provide targeting versatility with a quantitative control of the targeting effect by adjusting the lipid component ratio of the mixed lipid monolayer, and combine the advantages and avoid disadvantages of polymeric nanoparticles and liposomes in drug delivery. X-ray photoelectron spectroscopy (XPS) confirmed the coating of the mixed lipid monolayer on the polymeric core. Fluorescent microscopy proved the targeting efficacy of the folic acid conjugated on the mixed lipid monolayer for the cancer cells of over expression of folate receptors. The folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core were proved to possess sustainable, controlled and targeted delivery of anticancer drugs with Docetaxel as a model drug, which may provide a drug delivery system of precise control of the targeting effect. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/63938
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2009.09.036
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