Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2009.09.036
Title: Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel
Authors: Liu, Y.
Li, K.
Pan, J.
Liu, B. 
Feng, S.-S. 
Keywords: Cancer nanotechnology
Chemotherapeutic engineering
Nanomedicine
Receptor-mediated endocytosis (RME)
Surface conjugation
Taxanes
Issue Date: Jan-2010
Source: Liu, Y., Li, K., Pan, J., Liu, B., Feng, S.-S. (2010-01). Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel. Biomaterials 31 (2) : 330-338. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2009.09.036
Abstract: A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer core was developed for targeted delivery of anticancer drugs with Docetaxel as a model drug, which provide targeting versatility with a quantitative control of the targeting effect by adjusting the lipid component ratio of the mixed lipid monolayer, and combine the advantages and avoid disadvantages of polymeric nanoparticles and liposomes in drug delivery. X-ray photoelectron spectroscopy (XPS) confirmed the coating of the mixed lipid monolayer on the polymeric core. Fluorescent microscopy proved the targeting efficacy of the folic acid conjugated on the mixed lipid monolayer for the cancer cells of over expression of folate receptors. The folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core were proved to possess sustainable, controlled and targeted delivery of anticancer drugs with Docetaxel as a model drug, which may provide a drug delivery system of precise control of the targeting effect. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/63938
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2009.09.036
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

180
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

168
checked on Nov 18, 2017

Page view(s)

24
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.