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Title: Fluorescent detection of ATP based on signaling DNA aptamer attached silica nanoparticles
Authors: Wang, Y.
Wang, Y.
Liu, B. 
Issue Date: 15-Oct-2008
Source: Wang, Y.,Wang, Y.,Liu, B. (2008-10-15). Fluorescent detection of ATP based on signaling DNA aptamer attached silica nanoparticles. Nanotechnology 19 (41) : -. ScholarBank@NUS Repository.
Abstract: Novel methods for rapid, sensitive and low-cost biomolecule detection have attracted particular interest because of their wide use in medical diagnostics, food inspection and biomedical research applications. In this work, we report a simple and efficient silica nanoparticle (NP)-based fluorescent assay for ATP detection. It takes advantage of the washing and separation properties of NPs and the structure-switch property of DNA aptamers, resulting in fluorescence change of the supernatant in the presence of targets. A linear response for ATP detection was observed from 0 to 6 mM with a detection limit of ∼34 μM. This detection strategy could be generalized to other aptamer-based detection systems. © IOP Publishing Ltd.
Source Title: Nanotechnology
ISSN: 09574484
DOI: 41/415605
Appears in Collections:Staff Publications

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