Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2003.12.013
Title: Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)
Authors: Feng, S.-S. 
Ruan, G.
Li, Q.-T.
Keywords: DCM, dichloromethane
DOPC, 1,2-Dioleoyl-sn-glycero-3-phosphocholine
Double emulsion process, water-in-oil-in-water double emulsion solvent extraction/evaporation process
DPPG, 1,2-Dipalmitoyl-sn-glycero-3-(phospho-rac- (1-glycerol))
Issue Date: Sep-2004
Source: Feng, S.-S., Ruan, G., Li, Q.-T. (2004-09). Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM). Biomaterials 25 (21) : 5181-5189. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2003.12.013
Abstract: In the present work, we developed a novel drug delivery system, liposomes-in-microsphere (LIM) of biodegradable polymers, which is conceived from a combination of the polymer- and the lipid-based delivery systems and can thus integrate the advantages and avoid the drawbacks of the two systems. Liposomes were encapsulated into microspheres of biodegradable polymers by the solvent extraction/evaporation process to form LIMs. The integrity of the liposomes was preserved by modifying the microencapsulation process and coating the liposomes with chitosan. We demonstrated by scanning electron microscopy, laser light scattering and fluorescence spectroscopy that the particle size and surface morphology of the polymeric microspheres did not change significantly with the liposomes encapsulated, the liposomes remained intact within the polymeric matrix of the microspheres, and the encapsulated liposomes could be released from the microspheres in a controlled manner at a nearly constant release rate after an initial off-release period. Decreasing the particle size of liposomes and increasing the pore size of the polymeric matrix shortened the initial off-release period and increased the liposome release rate. In conclusion, a novel drug delivery system, liposomes-in-microsphere, was successfully developed and characterized. The liposome release kinetics could be controlled by the composition and fabrication parameters of the liposomes and polymeric microspheres. Such a novel controlled release system may have potential to be applied for drug delivery and gene therapy. © 2003 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/63899
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2003.12.013
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

69
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

54
checked on Nov 18, 2017

Page view(s)

26
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.