Please use this identifier to cite or link to this item: https://doi.org/10.1002/adsc.200900241
Title: Enantioselective benzylic hydroxylation with pseudomonas monteilii TA-5: A simple method for the syntheses of (R)-benzylic alcohols containing reactive functional groups
Authors: Chen, Y. 
Lie, F. 
Li, Z. 
Keywords: Asymmetric synthesis
Biotransformations
Chiral benzylic alcohols
Enzyme catalysis
Hydroxylation
Pseudomonas monteilii ta-5
Issue Date: Sep-2009
Source: Chen, Y., Lie, F., Li, Z. (2009-09). Enantioselective benzylic hydroxylation with pseudomonas monteilii TA-5: A simple method for the syntheses of (R)-benzylic alcohols containing reactive functional groups. Advanced Synthesis and Catalysis 351 (13) : 2107-2112. ScholarBank@NUS Repository. https://doi.org/10.1002/adsc.200900241
Abstract: Highly enantioselective benzylic hydroxylations of benzene derivatives (1-4) containing reactive functional groups were achieved for the first time with Pseudomonas monteilii TA-5 as biocatalyst, giving the corresponding (R)-benzylic alcohols 5-8 in 93-99% ee as the only products. Preparative biotransformations were demonstrated by the biohydroxylation of 1 and 2 with resting cells of P monteilii TA-5 to afford (R)-5 in 94% ee and 66% yield and (R)-6 in 94% ee and 56% yield, respectively. The highly enantioselective biohydroxylations represent a simple access to (R)-benzylic alcohols containing reactive functional groups that are useful pharmaceutical intermediates and versatile chiral building blocks. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title: Advanced Synthesis and Catalysis
URI: http://scholarbank.nus.edu.sg/handle/10635/63831
ISSN: 16154150
DOI: 10.1002/adsc.200900241
Appears in Collections:Staff Publications

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