Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jcrysgro.2010.11.105
Title: Effects of the rate of supersaturation generation on polymorphic crystallization of m-hydroxybenzoic acid and o-aminobenzoic acid
Authors: He, G.
Wong, A.B.H.
Chow, P.S.
Tan, R.B.H. 
Keywords: A1. Polymorphic crystallization
A1. Rate of supersaturation generation
A2. Cooling
A2. Evaporation
Issue Date: 1-Jan-2011
Source: He, G., Wong, A.B.H., Chow, P.S., Tan, R.B.H. (2011-01-01). Effects of the rate of supersaturation generation on polymorphic crystallization of m-hydroxybenzoic acid and o-aminobenzoic acid. Journal of Crystal Growth 314 (1) : 220-226. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jcrysgro.2010.11.105
Abstract: Effects of the rate of supersaturation generation on polymorphic crystallization have been investigated through evaporation and cooling crystallization experiments of m-hydroxybenzoic acid (m-HBA) in methanol, acetone and ethyl acetate, and o-aminobenzoic acid (o-ABA) in ethanol. The rate of supersaturation generation has been altered by systematically changing either the cooling rate or the evaporation rate of solvent using a jacketed crystallizer and a microfluidic evaporation device, respectively. The results have revealed that the rate of supersaturation generation and the tendency of the formation of the less stable polymorph are positively correlated. Kinetic effects are dominant when the rate of supersaturation generation is high, thereby producing the metastable polymorphs (orthorhombic m-HBA; Form II of o-ABA); on the contrary, more stable polymorphs (monoclinic m-HBA; Forms III and I of o-ABA) are formed when the rate of supersaturation generation is low and the thermodynamic effects are prevailing. © 2010 Elsevier B.V. All rights reserved.
Source Title: Journal of Crystal Growth
URI: http://scholarbank.nus.edu.sg/handle/10635/63794
ISSN: 00220248
DOI: 10.1016/j.jcrysgro.2010.11.105
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