Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2011.03.005
Title: Controlled antisolvent precipitation of spironolactone nanoparticles by impingement mixing
Authors: Dong, Y.
Ng, W.K.
Shen, S.
Kim, S.
Tan, R.B.H. 
Keywords: Antisolvent precipitation
Impingement mixing
Nanoparticles
Oral bioavailability
Spironolactone
Issue Date: 30-May-2011
Source: Dong, Y.,Ng, W.K.,Shen, S.,Kim, S.,Tan, R.B.H. (2011-05-30). Controlled antisolvent precipitation of spironolactone nanoparticles by impingement mixing. International Journal of Pharmaceutics 410 (1-2) : 175-179. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2011.03.005
Abstract: Continuous antisolvent precipitation of spironolactone nanoparticles were performed by impingement mixing in this work. In the range of Reynolds numbers (Re) 2108-6325 for the antisolvent water stream and 1771-5313 for the solvent stream, i.e. acetonic drug solution, 302-360 nm drug nanoparticles were achieved. Increasing drug concentration from 25 to 50 and 100 mg/ml led to a significant size increase from 279.0 ± 2.6 to 302.7 ± 4.9 and 446.0 ± 17.3 nm, respectively. "Two-step crystallization" was first observed for spironolactone in the water/acetone system: the drug was precipitated initially as spherical cluster, which rearranged into ordered cuboidal nanocrystals finally. The nanoformulation showed faster dissolution rate in comparison with the raw drug. By combining the impingement mixing and an on-line spray drying, a fully continuous process may be developed for mass-production of dried drug nanoparticles. © 2011 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/63659
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2011.03.005
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