Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0nr00950d
Title: Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking
Authors: Ding, D. 
Li, K.
Zhu, Z.
Pu, K.-Y. 
Hu, Y.
Jiang, X.
Liu, B. 
Issue Date: May-2011
Source: Ding, D., Li, K., Zhu, Z., Pu, K.-Y., Hu, Y., Jiang, X., Liu, B. (2011-05). Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking. Nanoscale 3 (5) : 1997-2002. ScholarBank@NUS Repository. https://doi.org/10.1039/c0nr00950d
Abstract: A molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense poly(ethylene glycol) (PEG) chains was successfully complexed with an anticancer agent, cisplatin, to form cisplatin-loaded nanoparticles (CPE-PEG-Pt). The obtained nanoparticles have high far-red/near-infrared fluorescence and are able to release the drug in a continuous and slow manner. These nanoparticles have not only been used to visualize HepG2 cancer cells, but also served as an in vivo fluorescent imaging probe that simultaneously tracks the in vivo drug distribution in nude mice upon intravenous administration. © 2011 The Royal Society of Chemistry.
Source Title: Nanoscale
URI: http://scholarbank.nus.edu.sg/handle/10635/63642
ISSN: 20403364
DOI: 10.1039/c0nr00950d
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