Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11458-009-0101-0
Title: Conjugated polyelectrolyte amplified fluorescent assays with probe functionalized silica nanoparticles for chemical and biological sensing
Authors: Wang, Y.
Liu, B. 
Keywords: Conjugated polyelectrolyte
DNA
Energy transfer
Protein
Sensor
Silica nanoparticle
Issue Date: Dec-2009
Source: Wang, Y.,Liu, B. (2009-12). Conjugated polyelectrolyte amplified fluorescent assays with probe functionalized silica nanoparticles for chemical and biological sensing. Frontiers of Chemistry in China 4 (4) : 325-334. ScholarBank@NUS Repository. https://doi.org/10.1007/s11458-009-0101-0
Abstract: Low-cost sensors with high sensitivity and selectivity for chemical and biological detection are of high scientific and economic importance. Silica nanoparticles (NPs) have shown vast promise in sensor applications by virtue of their controllable surface modification, good chemical stability, and biocompatibility. This mini-review summarizes our recent development of silica NP-based assays for chemical and biological detection, where silica NPs serve as the substrate for probe immobilization, target recognition, and separation. The assay performance is further improved through the introduction of conjugated polyelectrolyte to amplify the detection signal. The assays have been demonstrated to be successful for the detection of DNA, small molecules, and proteins. They could be generalized for other targets based on specific interactions, such as DNA hybridization, antibody-antigen recognition, and target-aptamer binding. © Higher Education Press and Springer-Verlag 2009.
Source Title: Frontiers of Chemistry in China
URI: http://scholarbank.nus.edu.sg/handle/10635/63638
ISSN: 16733495
DOI: 10.1007/s11458-009-0101-0
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