Please use this identifier to cite or link to this item:
Title: Conformational and enantiotropic polymorphism of a 1:1 cocrystal involving ethenzamide and ethylmalonic acid
Authors: Aitipamula, S.
Chow, P.S.
Tan, R.B.H. 
Issue Date: Nov-2010
Citation: Aitipamula, S., Chow, P.S., Tan, R.B.H. (2010-11). Conformational and enantiotropic polymorphism of a 1:1 cocrystal involving ethenzamide and ethylmalonic acid. CrystEngComm 12 (11) : 3691-3697. ScholarBank@NUS Repository.
Abstract: Polymorphism in cocrystals is increasingly gaining interest because of the overwhelming interest in pharmaceutical cocrystals. In this paper, we report a 1:1 cocrystal of an analgesic drug, ethenzamide (EA), with ethylmalonic acid (EMA) which exists in two polymorphic forms. Both the polymorphs were characterized by various analytical techniques, such as single-crystal and powder X-ray diffraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), hot-stage microscopy (HSM) and variable temperature X-ray diffraction (VTXRD). Crystal structure analysis suggests that the EMA molecules in both the polymorphs adopt different conformations but feature a common hydrogen bonding motif. Thermal analysis suggests that the polymorphs are related enantiotropically. Based on the information obtained from the thermal data and various other experiments, a semi-schematic energy-temperature diagram was constructed. Interestingly, it was observed that the polymorphic outcome of solid-state grinding is remarkably dependent on the polarity of the solvent used in the solvent-drop grinding experiments. © 2010 The Royal Society of Chemistry.
Source Title: CrystEngComm
ISSN: 14668033
DOI: 10.1039/c004491a
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Oct 20, 2018


checked on Oct 3, 2018

Page view(s)

checked on Oct 13, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.