Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cherd.2011.07.005
Title: Comparison of dielectric constant meter with turbidity meter and focused beam reflectance measurement for metastable zone width determination
Authors: He, G.
Hermanto, M.W.
Tjahjono, M.
Chow, P.S.
Tan, R.B.H. 
Garland, M.
Keywords: Dielectric constant
Metastable zone width
Phase transition
Process analytical technology
Issue Date: Feb-2012
Source: He, G., Hermanto, M.W., Tjahjono, M., Chow, P.S., Tan, R.B.H., Garland, M. (2012-02). Comparison of dielectric constant meter with turbidity meter and focused beam reflectance measurement for metastable zone width determination. Chemical Engineering Research and Design 90 (2) : 259-265. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cherd.2011.07.005
Abstract: This work demonstrates a detailed process analytical technology (PAT) comparison study of dielectric constant measurement with turbidity measurement and focused beam reflectance measurement (FBRM) in detecting phase transitions during crystallization of three model solutions, namely stearic acid-ethyl acetate, paracetamol-ethanol and carbamazepine-methanol. The cloud and clear points determined by the dielectric constant measurement are found to be in close agreement with those obtained from the other two well-established PAT tools. A calibration technique can be further applied on the dielectric constant to improve the accuracy of the cloud point detection. The results have shown that the dielectric constant meter can be reliably used for metastable zone width (MZW) determination. This study opens new opportunities for the use of the dielectric constant meter as a simple and inexpensive alternative PAT tool for process monitoring of solution crystallization. © 2011.
Source Title: Chemical Engineering Research and Design
URI: http://scholarbank.nus.edu.sg/handle/10635/63617
ISSN: 02638762
DOI: 10.1016/j.cherd.2011.07.005
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