Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.200600821
Title: Collective response from a cationic tetrahedral fluorene for label-free DNA detection
Authors: Liu, B. 
Dan, T.T.T.
Bazan, G.C.
Issue Date: 24-Sep-2007
Source: Liu, B., Dan, T.T.T., Bazan, G.C. (2007-09-24). Collective response from a cationic tetrahedral fluorene for label-free DNA detection. Advanced Functional Materials 17 (14) : 2432-2438. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.200600821
Abstract: A cationic water-soluble tetrahedral molecule bearing four phenylene-bis(fluorene) optical units, namely tefrakis[4-(2-(9,9,9′, 9′-tetrakis(N,N,N-trimethylammomumhexyl)-7,2′-bifluorenyl))-phenyl] methane hexadecanebromide, was designed and synthesized. Fluorescence resonance energy transfer (FRET) experiments between the tetrahedral molecule and fluorescein-labeled double stranded DNA (dsDNA-Fl) or single stranded DNA (ssDNA-Fl) were undertaken. Due to its specific shape and spatial registry, the tetrahedral molecule shows improved FRET efficiencies to dsDNA-Fl as well as improved selectivity between dsDNA and ssDNA, when compared to a cationic conjugated polymer with similar repeat units. 30-Fold signal amplification for dsDNA/ethidium bromide (EB) and selective response between complementary and non-complementary DNA indicates that tetrahedral molecules could be useful to amplify the optical response from EB-based DNA protocols. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.
Source Title: Advanced Functional Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/63602
ISSN: 1616301X
DOI: 10.1002/adfm.200600821
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

48
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

41
checked on Nov 17, 2017

Page view(s)

35
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.