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https://doi.org/10.1002/adfm.200600821
Title: | Collective response from a cationic tetrahedral fluorene for label-free DNA detection | Authors: | Liu, B. Dan, T.T.T. Bazan, G.C. |
Issue Date: | 24-Sep-2007 | Citation: | Liu, B., Dan, T.T.T., Bazan, G.C. (2007-09-24). Collective response from a cationic tetrahedral fluorene for label-free DNA detection. Advanced Functional Materials 17 (14) : 2432-2438. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.200600821 | Abstract: | A cationic water-soluble tetrahedral molecule bearing four phenylene-bis(fluorene) optical units, namely tefrakis[4-(2-(9,9,9′, 9′-tetrakis(N,N,N-trimethylammomumhexyl)-7,2′-bifluorenyl))-phenyl] methane hexadecanebromide, was designed and synthesized. Fluorescence resonance energy transfer (FRET) experiments between the tetrahedral molecule and fluorescein-labeled double stranded DNA (dsDNA-Fl) or single stranded DNA (ssDNA-Fl) were undertaken. Due to its specific shape and spatial registry, the tetrahedral molecule shows improved FRET efficiencies to dsDNA-Fl as well as improved selectivity between dsDNA and ssDNA, when compared to a cationic conjugated polymer with similar repeat units. 30-Fold signal amplification for dsDNA/ethidium bromide (EB) and selective response between complementary and non-complementary DNA indicates that tetrahedral molecules could be useful to amplify the optical response from EB-based DNA protocols. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA. | Source Title: | Advanced Functional Materials | URI: | http://scholarbank.nus.edu.sg/handle/10635/63602 | ISSN: | 1616301X | DOI: | 10.1002/adfm.200600821 |
Appears in Collections: | Staff Publications |
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