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|Title:||Collective response from a cationic tetrahedral fluorene for label-free DNA detection|
|Authors:||Liu, B. |
|Source:||Liu, B., Dan, T.T.T., Bazan, G.C. (2007-09-24). Collective response from a cationic tetrahedral fluorene for label-free DNA detection. Advanced Functional Materials 17 (14) : 2432-2438. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.200600821|
|Abstract:||A cationic water-soluble tetrahedral molecule bearing four phenylene-bis(fluorene) optical units, namely tefrakis[4-(2-(9,9,9′, 9′-tetrakis(N,N,N-trimethylammomumhexyl)-7,2′-bifluorenyl))-phenyl] methane hexadecanebromide, was designed and synthesized. Fluorescence resonance energy transfer (FRET) experiments between the tetrahedral molecule and fluorescein-labeled double stranded DNA (dsDNA-Fl) or single stranded DNA (ssDNA-Fl) were undertaken. Due to its specific shape and spatial registry, the tetrahedral molecule shows improved FRET efficiencies to dsDNA-Fl as well as improved selectivity between dsDNA and ssDNA, when compared to a cationic conjugated polymer with similar repeat units. 30-Fold signal amplification for dsDNA/ethidium bromide (EB) and selective response between complementary and non-complementary DNA indicates that tetrahedral molecules could be useful to amplify the optical response from EB-based DNA protocols. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.|
|Source Title:||Advanced Functional Materials|
|Appears in Collections:||Staff Publications|
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