Please use this identifier to cite or link to this item:
|Title:||Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres|
|Keywords:||Coaxial electrohydrodynamic atomization|
Core-shell structured microspheres
|Citation:||Xu, Q., Qin, H., Yin, Z., Hua, J., Pack, D.W., Wang, C.-H. (2013-12-18). Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres. Chemical Engineering Science 104 : 330-346. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ces.2013.09.020|
|Abstract:||Polymeric composite microspheres consisting of a poly( d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly( d,. l-lactic acid) (PDLLA) shell layer were successfully fabricated by coaxial electrohydrodynamic atomization (CEHDA) process. Process conditions, including nozzle voltage and polymer solution flow rates, as well as solution parameters, such as polymer concentrations, were investigated to ensure the formation of composite microspheres with a doxorubicin-loaded PLGA core surrounded by a relatively drug-free PDLLA shell layer. Various microsphere formulations were fabricated and characterized in terms of their drug distribution, encapsulation efficiency and in vitro release. Numerical simulation of CEHDA process was performed based on a computational fluid dynamics (CFD) model in Fluent by employing the process conditions and fluid properties used in the experiments. The simulation results were compared with the experimental work to illustrate the capability of the CFD model to predict the production of consistent compound droplets, and hence, the expected core-shell structured microspheres.© 2013 Elsevier Ltd.|
|Source Title:||Chemical Engineering Science|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 16, 2018
WEB OF SCIENCETM
checked on Oct 8, 2018
checked on Sep 29, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.