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Title: Carboxymethyl chitosan-functionalized magnetic nanoparticles for disruption of biofilms of staphylococcus aureus and escherichia coli
Authors: Chen, T.
Wang, R.
Xu, L.Q.
Neoh, K.G. 
Kang, E.T. 
Issue Date: 10-Oct-2012
Citation: Chen, T., Wang, R., Xu, L.Q., Neoh, K.G., Kang, E.T. (2012-10-10). Carboxymethyl chitosan-functionalized magnetic nanoparticles for disruption of biofilms of staphylococcus aureus and escherichia coli. Industrial and Engineering Chemistry Research 51 (40) : 13164-13172. ScholarBank@NUS Repository.
Abstract: Bacteria in biofilms are much more resistant to antibiotics and microbicides as compared to their planktonic stage. Thus, to achieve the same antibacterial efficacy, a much higher dose of antibiotics is required for biofilm bacteria. However, the widespread use of antibiotics has been recognized as the main cause for the emergence of antibiotic-resistant microbial species, which has now become a major public health crisis globally. In this work, we present an efficient nonantibiotic-based strategy for disrupting biofilms using carboxymethyl chitosan (CMCS) coated on magnetic iron oxide nanoparticles (CMCS-MNPs). CMCS-MNPs demonstrate strong bactericidal activities against both Gram-positive Staphylococcus aureus (S. aureus) and Gramnegative Escherichia coli (E. coli) planktonic cells. More than 99% S. aureus and E. coli planktonic cells were killed after incubation with CMCS-MNPs for 10 and 5 h, respectively. In the presence of a magnetic field (MF), CMCS-MNPs can effectively penetrate into both S. aureus and E. coli biofilms, resulting in a reduction of viable cells counts by 84% and 95%, respectively, after 48 h incubation, as compared to the control experiment without CMCS-MNPs or CMCS. CMCS-MNPs are noncytotoxic toward mammalian cells and can potentially be a useful antimicrobial agent to eliminate both planktonic and biofilm bacteria. © 2012 American Chemical Society.
Source Title: Industrial and Engineering Chemistry Research
ISSN: 08885885
DOI: 10.1021/ie301522w
Appears in Collections:Staff Publications

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