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|Title:||Biocompatible organic dots with aggregation-induced emission for in vitro and in vivo fluorescence imaging|
|Citation:||Li, K., Ding, D., Zhao, Q., Sun, J., Tang, B.Z., Liu, B. (2013-09). Biocompatible organic dots with aggregation-induced emission for in vitro and in vivo fluorescence imaging. Science China Chemistry 56 (9) : 1228-1233. ScholarBank@NUS Repository. https://doi.org/10.1007/s11426-013-4936-3|
|Abstract:||Fluorescent probes play a key role in modern biomedical research. As compared to inorganic quantum dots (QDs) composed with heavy metal elements, organic dye-based fluorescent nanoparticles have higher biocompatibility and are richer in variety. However, traditional organic fluorophores tend to quench fluorescence upon aggregation, which is known as aggregation-caused quenching (ACQ) effect that hinders the fabrication of highly emissive fluorescent nanoparticles. In this work, we demonstrate the synthesis of organic fluorescent dots with aggregation-induced emission (AIE) in far-red/near-infrared (FA/NIR) region. A conventional ACQ-characteristic fluorescent dye, 3,4:9,10- tetracarboxylic perylene bisimide (PBI), is converted into an AIE fluorogen through attaching two tetraphenylethylene (TPE) moieties. The fluorescent dots with surface folic acid groups are fabricated from PBI derivative (DTPEPBI), showing specific targeting effect to folate receptor-overexpressed cancer cells. In vivo studies also suggest that the folic acid-functionalized AIE dots preferentially accumulate in the tumor site through enhanced permeability and retention (EPR) effect and folate receptor-mediated active targeting effect. The low cytotoxicity, good FR/NIR contrast and excellent targeting ability in in vitro/in vivo imaging indicate that the AIE dots have great potentials in advanced bioimaging applications. © 2013 Science China Press and Springer-Verlag Berlin Heidelberg.|
|Source Title:||Science China Chemistry|
|Appears in Collections:||Staff Publications|
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