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Title: Binderless fluidized bed granulation of a type C hygroscopic pharmaceutical powder with prior humidification treatment
Authors: Ng, W.K.
Shen, S.C.
Tan, R.B.H. 
Keywords: Binderless
Type C particles
Issue Date: 15-Feb-2011
Source: Ng, W.K., Shen, S.C., Tan, R.B.H. (2011-02-15). Binderless fluidized bed granulation of a type C hygroscopic pharmaceutical powder with prior humidification treatment. Powder Technology 207 (1-3) : 9-16. ScholarBank@NUS Repository.
Abstract: Geldart Type C powder is very fine and cohesive and therefore, very difficult to be fluidized or processed. Severe channeling tends to occur as the inter-particle forces cannot be overcome by the air streams. In this industrial process study, humidification is employed prior fluidized bed granulation to convert a Type C powder to Type A, which is less cohesive and can be readily fluidized. This method was applied to granulate a Type C active pharmaceutical ingredient (API) used for asthma treatment. The API was humidified at approx. 71 to 75% relative humidity and temperatures ranging from 21 to 45 °C over durations of 20 to 60. h. Humidification of the sharp edged particles resulted in the rounding and smoothening of surface morphology due to dissolution, re-crystallization and fusion of contact surfaces. The particle size is increased due to agglomeration. Due to moisture sorption, even without a binder, the humidified material can be readily granulated inside a fluidized bed to form sphere-like agglomerates with improved flowability. © 2010 Elsevier B.V.
Source Title: Powder Technology
ISSN: 00325910
DOI: 10.1016/j.powtec.2010.10.004
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