Please use this identifier to cite or link to this item: https://doi.org/10.1021/cg060822t
Title: Automated in-line technique using FBRM to achieve consistent product quality in cooling crystallization
Authors: Chew, J.W.
Chow, P.S.
Tan, R.B.H. 
Issue Date: Aug-2007
Citation: Chew, J.W., Chow, P.S., Tan, R.B.H. (2007-08). Automated in-line technique using FBRM to achieve consistent product quality in cooling crystallization. Crystal Growth and Design 7 (8) : 1416-1422. ScholarBank@NUS Repository. https://doi.org/10.1021/cg060822t
Abstract: An in-line technique involving focused beam reflectance measurement (FBRM) for control of crystal product quality in unseeded systems is proposed. The method consists of nucleation detection followed by a holding time to internally generate seeds through primary nucleation and then controlled conditioning of these seeds using FBRM measurement of the particle size distribution (PSD). The technique has been successfully implemented for the cooling crystallization of glycine and paracetamol in water. Results showed that the crystal product consistency using our technique was comparable to that of externally seeded crystallizations. © 2007 American Chemical Society.
Source Title: Crystal Growth and Design
URI: http://scholarbank.nus.edu.sg/handle/10635/63521
ISSN: 15287483
DOI: 10.1021/cg060822t
Appears in Collections:Staff Publications

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