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|Title:||Antimicrobial surfaces of viologen-quaternized poly((2-dimethyl amino)ethyl methacrylate)-Si(100) hybrids from surface-initiated atom transfer radical polymerization|
|Authors:||Xu, F.J. |
|Source:||Xu, F.J.,Yuan, S.J.,Pehkonen, S.O.,Kang, E.T.,Neoh, K.G. (2006-09). Antimicrobial surfaces of viologen-quaternized poly((2-dimethyl amino)ethyl methacrylate)-Si(100) hybrids from surface-initiated atom transfer radical polymerization. Nanobiotechnology 2 (3-4) : 123-134. ScholarBank@NUS Repository. https://doi.org/10.1007/BF02697267|
|Abstract:||To improve the antimicrobial ability of silicon-based bioelectronics and to tailor the silicon surfaces for inhibiting biofilm formation, well-defined functional polymer-Si(100) hybrids, consisting of nearly monodispersed poly((2-dimethylamino)ethyl methacrylate) (P(DMAEMA)) covalently tethered on the silicon surface and functionalized by viologen moieties, were prepared. P(DMAEMA)-Si hybrids were prepared via surface-initiated atom transfer radical polymerization (ATRP) of (2-dimethylamino)ethyl methacrylate (DMAEMA) on the hydrogen-terminated Si(100) surfaces (Si-H surfaces). The tertiary amino groups of the covalently immobilized (Si-C bonded) P(DMAEMA) brushes on the silicon substrates were quaternized by an alkyl halide to produce a high concentration of quaternary ammonium groups with biocidal functionality. Alternatively, covalent coupling of viologen moieties to the tertiary amino groups of P(DMAEMA) brushes produced the quaternized P(DMAEMA)-Si(100) hybrids with substantially enhanced antimicrobial capability, as well as capability to effectively inhibit biofilm formation. Thus, the viologen-quaternized P(DMAEMA)-Si(100) hybrids possess good antibacterial surface properties and are potentially useful to the silicon-based bioelectronics to ensure their efficiency, durability and reliability. Copyright © 2006 Humana Press Inc. All rights of any nature whatsoever are reserved.|
|Appears in Collections:||Staff Publications|
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