Please use this identifier to cite or link to this item: https://doi.org/10.1002/bit.20384
Title: Antibacterial and antifungal efficacy of surface functionalized polymeric beads in repeated applications
Authors: Hu, F.X.
Neoh, K.G. 
Cen, L. 
Kang, E.T. 
Keywords: Antibacterial
Antifungal
Microbeads
Pyridinium
Surface functionalization
Issue Date: 20-Feb-2005
Citation: Hu, F.X., Neoh, K.G., Cen, L., Kang, E.T. (2005-02-20). Antibacterial and antifungal efficacy of surface functionalized polymeric beads in repeated applications. Biotechnology and Bioengineering 89 (4) : 474-484. ScholarBank@NUS Repository. https://doi.org/10.1002/bit.20384
Abstract: A simple method was developed to prepare polymeric microbeads with antibacterial and antifungal properties. The microbeads of approximately spherical shape and narrow size distribution were prepared from a mixture of poly (4-vinyl pyridine) (P4VP) and poly (vinylidene fluoride) (PVDF) by a phase inversion technique and subsequently derivatized with alkyl bromides having 4-10 carbon atoms. The quaternization of the pyridine groups into pyridinium groups confers the surface with highly effective and long-lasting antibacterial and antifungal properties, as shown by the effect on Escherichia coli and Aspergillus niger. Upon contact with the N-alkylated beads, the bacteria and fungal spores are lysed and intracellular constituents leach out into the medium. The efficacy of the alkyl chains in disrupting the cell membrane was investigated. The stability of the functional group and microbiocidal effectiveness of the microbeads in repeated applications was also assessed. © 2004 Wiley Periodicals, Inc.
Source Title: Biotechnology and Bioengineering
URI: http://scholarbank.nus.edu.sg/handle/10635/63487
ISSN: 00063592
DOI: 10.1002/bit.20384
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

63
checked on Dec 10, 2018

WEB OF SCIENCETM
Citations

55
checked on Dec 10, 2018

Page view(s)

47
checked on Dec 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.