Please use this identifier to cite or link to this item:
|Title:||Antibacterial and antifungal efficacy of surface functionalized polymeric beads in repeated applications|
|Citation:||Hu, F.X., Neoh, K.G., Cen, L., Kang, E.T. (2005-02-20). Antibacterial and antifungal efficacy of surface functionalized polymeric beads in repeated applications. Biotechnology and Bioengineering 89 (4) : 474-484. ScholarBank@NUS Repository. https://doi.org/10.1002/bit.20384|
|Abstract:||A simple method was developed to prepare polymeric microbeads with antibacterial and antifungal properties. The microbeads of approximately spherical shape and narrow size distribution were prepared from a mixture of poly (4-vinyl pyridine) (P4VP) and poly (vinylidene fluoride) (PVDF) by a phase inversion technique and subsequently derivatized with alkyl bromides having 4-10 carbon atoms. The quaternization of the pyridine groups into pyridinium groups confers the surface with highly effective and long-lasting antibacterial and antifungal properties, as shown by the effect on Escherichia coli and Aspergillus niger. Upon contact with the N-alkylated beads, the bacteria and fungal spores are lysed and intracellular constituents leach out into the medium. The efficacy of the alkyl chains in disrupting the cell membrane was investigated. The stability of the functional group and microbiocidal effectiveness of the microbeads in repeated applications was also assessed. © 2004 Wiley Periodicals, Inc.|
|Source Title:||Biotechnology and Bioengineering|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 19, 2018
WEB OF SCIENCETM
checked on Sep 5, 2018
checked on Jul 27, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.