Please use this identifier to cite or link to this item: https://doi.org/10.1002/aic.12373
Title: Acid-sensitive magnetic nanoparticles as potential drug depots
Authors: Wuang, S.C. 
Neoh, K.G. 
Kang, E.-T. 
Leckband, D.E.
Pack, D.W.
Keywords: Cancer cells
Conjugation
Doxorubicin
Hydrazone linkages
Magnetic drug targeting
Magnetic nanoparticles
Poly(methacrylic acid)
Issue Date: Jun-2011
Source: Wuang, S.C., Neoh, K.G., Kang, E.-T., Leckband, D.E., Pack, D.W. (2011-06). Acid-sensitive magnetic nanoparticles as potential drug depots. AIChE Journal 57 (6) : 1638-1645. ScholarBank@NUS Repository. https://doi.org/10.1002/aic.12373
Abstract: Superparamagnetic magnetic nanoparticles were successfully functionalized with poly(methacrylic acid) via atom transfer radical polymerization, followed by conjugation to doxorubicin (Dox). Because of pH-sensitive hydrazone linkages, the rate and extent of Dox release from the particles was higher at a lower pH and/or a higher temperature than at physiological conditions. Appropriate changes to the pH and temperature can increase the drug release from the particles. Because of the released drug, the particles were found to be cytotoxic to human breast cancer cells in vitro. Such magnetic nanoparticles, with the potential to retain drug under physiological conditions and release the drug in conditions where the pH is lower or temperature is higher, may be useful in magnetic drug targeting by reducing the side effects of the drug caused to healthy tissues. In addition, they may serve as hyperthermia agents where the high temperatures used in hyperthermia can trigger further drug release. © 2010 American Institute of Chemical Engineers (AIChE).
Source Title: AIChE Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/63428
ISSN: 00011541
DOI: 10.1002/aic.12373
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