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|Title:||Real-time control of a microfluidic channel for size-independent deformability cytometry|
|Source:||Guan, G.,Chen, P.C.Y.,Peng, W.K.,Bhagat, A.A.,Ong, C.J.,Han, J. (2012-10). Real-time control of a microfluidic channel for size-independent deformability cytometry. Journal of Micromechanics and Microengineering 22 (10) : -. ScholarBank@NUS Repository. https://doi.org/10/105037|
|Abstract:||Mechanical properties of cells can be correlated with various cell states and are now considered as an important class of biophysical markers. Effectiveness of existing high-throughput microfluidic techniques for investigating cell mechanical properties is adversely affected by cell-size variation in a given cell population. In this work, we introduce a new microfluidic system with real-time feedback control to evaluate single-cell deformability while minimizing cell-size dependence of the measurement. Using breast cancer cells (MCF-7), we demonstrate the potential of this system for stiffness profiling of cells in complex, diverse cell populations. © 2012 IOP Publishing Ltd.|
|Source Title:||Journal of Micromechanics and Microengineering|
|Appears in Collections:||Staff Publications|
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