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Title: Real-time control of a microfluidic channel for size-independent deformability cytometry
Authors: Guan, G.
Chen, P.C.Y. 
Peng, W.K.
Bhagat, A.A.
Ong, C.J. 
Han, J.
Issue Date: Oct-2012
Source: Guan, G., Chen, P.C.Y., Peng, W.K., Bhagat, A.A., Ong, C.J., Han, J. (2012-10). Real-time control of a microfluidic channel for size-independent deformability cytometry. Journal of Micromechanics and Microengineering 22 (10) : -. ScholarBank@NUS Repository.
Abstract: Mechanical properties of cells can be correlated with various cell states and are now considered as an important class of biophysical markers. Effectiveness of existing high-throughput microfluidic techniques for investigating cell mechanical properties is adversely affected by cell-size variation in a given cell population. In this work, we introduce a new microfluidic system with real-time feedback control to evaluate single-cell deformability while minimizing cell-size dependence of the measurement. Using breast cancer cells (MCF-7), we demonstrate the potential of this system for stiffness profiling of cells in complex, diverse cell populations. © 2012 IOP Publishing Ltd.
Source Title: Journal of Micromechanics and Microengineering
ISSN: 09601317
DOI: 10.1088/0960-1317/22/10/105037
Appears in Collections:Staff Publications

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