Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jbiomech.2010.12.014
Title: Investigation of hemodynamics in the development of dissecting aneurysm within patient-specific dissecting aneurismal aortas using computational fluid dynamics (CFD) simulations
Authors: Tse, K.M.
Chiu, P.
Lee, H.P. 
Ho, P.
Keywords: Aortic dissecting aneurysm
Computational fluid dynamics (CFD) simulation
Hemodynamics
Lumenal aneursym
Pre- and post-aneurismal patient-specific models
Issue Date: 15-Mar-2011
Source: Tse, K.M., Chiu, P., Lee, H.P., Ho, P. (2011-03-15). Investigation of hemodynamics in the development of dissecting aneurysm within patient-specific dissecting aneurismal aortas using computational fluid dynamics (CFD) simulations. Journal of Biomechanics 44 (5) : 827-836. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jbiomech.2010.12.014
Abstract: Aortic dissecting aneurysm is one of the most catastrophic cardiovascular emergencies that carries high mortality. It was pointed out from clinical observations that the aneurysm development is likely to be related to the hemodynamics condition of the dissected aorta. In order to gain more insight on the formation and progression of dissecting aneurysm, hemodynamic parameters including flow pattern, velocity distribution, aortic wall pressure and shear stress, which are difficult to measure in vivo, are evaluated using numerical simulations. Pulsatile blood flow in patient-specific dissecting aneurismal aortas before and after the formation of lumenal aneurysm (pre-aneurysm and post-aneurysm) is investigated by computational fluid dynamics (CFD) simulations. Realistic time-dependent boundary conditions are prescribed at various arteries of the complete aorta models. This study suggests the helical development of false lumen around true lumen may be related to the helical nature of hemodynamic flow in aorta. Narrowing of the aorta is responsible for the massive recirculation in the poststenosis region in the lumenal aneurysm development. High pressure difference of 0.21. kPa between true and false lumens in the pre-aneurismal aorta infers the possible lumenal aneurysm site in the descending aorta. It is also found that relatively high time-averaged wall shear stress (in the range of 4-8. kPa) may be associated with tear initiation and propagation. CFD modeling assists in medical planning by providing blood flow patterns, wall pressure and wall shear stress. This helps to understand various phenomena in the development of dissecting aneurysm. © 2011 Elsevier Ltd.
Source Title: Journal of Biomechanics
URI: http://scholarbank.nus.edu.sg/handle/10635/60604
ISSN: 00219290
DOI: 10.1016/j.jbiomech.2010.12.014
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