Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1525-1594.2006.00239.x
Title: In vitro culture of human dermal fibroblasts on electrospun polycaprolactone collagen nanofibrous membrane
Authors: Venugopal, J.R. 
Zhang, Y. 
Ramakrishna, S. 
Keywords: Collagen
Electrospinning
Fibroblasts
Nanofibers
Polycaprolactone
Issue Date: Jun-2006
Source: Venugopal, J.R., Zhang, Y., Ramakrishna, S. (2006-06). In vitro culture of human dermal fibroblasts on electrospun polycaprolactone collagen nanofibrous membrane. Artificial Organs 30 (6) : 440-446. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1525-1594.2006.00239.x
Abstract: Novel cost-effective electrospun nanofibrous membrane is established for wound dressing and allogeneic cultured dermal substitute through the cultivation of human dermal fibroblast for skin defects. Synthetic polymers are generally used for tissue engineering and drug delivery applications because of their remarkable mechanical stability and slow degradation. Polycaprolactone (PCL) is used as a bioresorbable polymer in numerous medical devices as well as for tissue engineering applications. The large surface area of the polymer nanofibers with specific modifications facilitates cell adhesion and control of their cellular functions. The objectives of this study was to fabricate electrospun nanofibrous membrane from biodegradable PCL for wound dressing and collagen-blended nanofibrous membrane, and to examine fibroblast attachment, cell proliferation, and morphology of cell matrix interaction. Results of the present investigation prove that the porous nanofibrous membrane is suitable for wound dressing and modified PCL-blended collagen nanofibrous membrane is suitable for the attachment and proliferation of fibroblast, and might have the potential to be applied in tissue engineering as a dermal substitute for the treatment of skin defects and burn wounds. © 2006, Copyright the Authors.
Source Title: Artificial Organs
URI: http://scholarbank.nus.edu.sg/handle/10635/60510
ISSN: 0160564X
DOI: 10.1111/j.1525-1594.2006.00239.x
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