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Title: Fused deposition modeling of novel scaffold architectures for tissue engineering applications
Authors: Zein, I.
Hutmacher, D.W. 
Tan, K.C.
Teoh, S.H. 
Keywords: Bioresorbable polymer
Compressive properties
Fused deposition modeling
Interconnected channel network
Tissue engineering
Issue Date: 15-Feb-2002
Citation: Zein, I., Hutmacher, D.W., Tan, K.C., Teoh, S.H. (2002-02-15). Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 23 (4) : 1169-1185. ScholarBank@NUS Repository.
Abstract: Fused deposition modeling, a rapid prototyping technology, was used to produce novel scaffolds with honeycomb-like pattern, fully interconnected channel network, and controllable porosity and channel size. A bioresorbable polymer poly(ε-caprolactone) (PCL) was developed as a filament modeling material to produce porous scaffolds, made of layers of directionally aligned microfilaments, using this computer-controlled extrusion and deposition process. The PCL scaffolds were produced with a range of channel size 160-700μm, filament diameter 260-370μm and porosity 48-77%, and regular geometrical honeycomb pores, depending on the processing parameters. The scaffolds of different porosity also exhibited a pattern of compressive stress-strain behavior characteristic of porous solids under such loading. The compressive stiffness ranged from 4 to 77MPa, yield strength from 0.4 to 3.6MPa and yield strain from 4% to 28%. Analysis of the measured data shows a high correlation between the scaffold porosity and the compressive properties based on a power-law relationship. © 2001 Elsevier Science Ltd. All rights reserved.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/S0142-9612(01)00232-0
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