Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jbiotec.2005.03.021
Title: Flow modelling within a scaffold under the influence of uni-axial and bi-axial bioreactor rotation
Authors: Singh, H.
Teoh, S.H. 
Low, H.T. 
Hutmacher, D.W. 
Keywords: Bioreactor
Computational fluid dynamics
Tissue engineering
Issue Date: 23-Sep-2005
Source: Singh, H., Teoh, S.H., Low, H.T., Hutmacher, D.W. (2005-09-23). Flow modelling within a scaffold under the influence of uni-axial and bi-axial bioreactor rotation. Journal of Biotechnology 119 (2) : 181-196. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jbiotec.2005.03.021
Abstract: The problem of donor scarcity has led to the recent development of tissue engineering technologies, which aim to create implantable tissue equivalents for clinical transplantation. These replacement tissues are being realised through the use of biodegradable polymer scaffolds; temporary/permanent substrates, which facilitate cell attachment, proliferation, retention and differentiated tissue function. To optimise gas transfer and nutrient delivery, as well as to mimic the fluid dynamic environment present within the body, a dynamic system might be chosen. Experiments have shown that dynamic systems enhance tissue growth, with the aid of scaffolds, as compared to static culture systems. Very often, tissue growth within scaffolds is only seen to occur at the periphery. The present study utilises the Computational Fluid Dynamics package FLUENT, to provide a better understanding of the flow phenomena in scaffolds, within our novel bioreactor system. The uni-axial and bi-axial rotational schemes are studied and compared, based on a vessel rotating speed of 35 rpm. The wall shear stresses within and without the constructs are also studied. Findings show that bi-axial rotation of the vessel results in manifold increases of fluid velocity within the constructs, relative to uni-axial rotation about the X- and Z-axes, respectively. © 2005 Elsevier B.V. All rights reserved.
Source Title: Journal of Biotechnology
URI: http://scholarbank.nus.edu.sg/handle/10635/60344
ISSN: 01681656
DOI: 10.1016/j.jbiotec.2005.03.021
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