Please use this identifier to cite or link to this item: https://doi.org/2/025019
Title: Fabrication of nano-hydroxyapatite/collagen/osteonectin composites for bone graft applications
Authors: Liao, S. 
Ngiam, M.
Chan, C.K. 
Ramakrishna, S. 
Issue Date: 2009
Source: Liao, S.,Ngiam, M.,Chan, C.K.,Ramakrishna, S. (2009). Fabrication of nano-hydroxyapatite/collagen/osteonectin composites for bone graft applications. Biomedical Materials 4 (2) : -. ScholarBank@NUS Repository. https://doi.org/2/025019
Abstract: Mineralized type I collagen (collagen I) nanofibers and their nanofibril bundles make up the microstructure of natural bone tissue, which range from nanometers to micrometers. However, attempts to achieve this hierarchically assembled structure in vitro have been unsuccessful. In this study, we added osteonectin into the collagen I solution, either at a high or low weight ratio (osteonectin: collagen I = 1:30 or 1:90) before co-precipitation. Results indicated that spindle-like nano-hydroxyapatite (nano-HA) was deposited on collagen/osteonectin and pure osteonectin (control) groups. Furthermore, transmission electron microscope (TEM) and scanning electron microscope (SEM) results showed that the assembled mineralized fiber bundles were formed randomly at different levels from 50 nm, 250 nm to 1100 nm. However, when we replaced collagen I with collagen II, osteonectin addition did not induce the formation of mineralized fiber bundles. The participation of osteonectin in the assembly of the mineralized fibers could provide new insights into the novel mineralization function of osteonectin for bone development in vivo and advancing new biomimetic methods for bone graft applications. © 2009 IOP Publishing Ltd.
Source Title: Biomedical Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/60287
ISSN: 17486041
DOI: 2/025019
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

27
checked on Dec 8, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.