Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.polymer.2009.06.025
Title: Fabrication and characterization of poly(l-lactic acid) 3D nanofibrous scaffolds with controlled architecture by liquid-liquid phase separation from a ternary polymer-solvent system
Authors: He, L. 
Zhang, Y.
Zeng, X.
Quan, D.
Liao, S. 
Zeng, Y.
Lu, J.
Ramakrishna, S. 
Keywords: Crystalline form
Nanofibrous scaffold
Phase separation
Issue Date: 31-Jul-2009
Source: He, L., Zhang, Y., Zeng, X., Quan, D., Liao, S., Zeng, Y., Lu, J., Ramakrishna, S. (2009-07-31). Fabrication and characterization of poly(l-lactic acid) 3D nanofibrous scaffolds with controlled architecture by liquid-liquid phase separation from a ternary polymer-solvent system. Polymer 50 (16) : 4128-4138. ScholarBank@NUS Repository. https://doi.org/10.1016/j.polymer.2009.06.025
Abstract: Poly(l-lactic acid) (PLLA) three-dimensional (3D) scaffold with macro/micropores and nanofibrous structure was fabricated by phase separation from a ternary PLLA/dioxane/water system. The pore size was mainly determined by the coarsening effects in the phase separation process, while the nanofibrous structure was due to the formation of PLLA microcrystallite domains in the gelation process. Increasing the gelation temperature or the content of water in the mixed solvent system, the pore size definitely increased and macropores up to 300 μm were observed. However, coalescence of nanofibers occurred, even platelet-like structure appeared at gelation temperatures higher than 12 °C or the proportion of water exceeded 12%. X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) analyses demonstrated that the crystallinity degree increased with increasing the gelation temperature or the non-solvent volume ratio in the mixed system. Moreover, the results indicated that α′ was mainly corresponding to the nanofibers structure, while α crystal was detected in the platelet-like structure. Scanning electron micrograph (SEM) and methyl thiazolyl tetrazolium (MTT) assays indicated that the nanofibrous scaffold provided a better attachment and viability of MSCs (rat derived mesenchymal stem cells) than the platelet-like scaffold. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Polymer
URI: http://scholarbank.nus.edu.sg/handle/10635/60275
ISSN: 00323861
DOI: 10.1016/j.polymer.2009.06.025
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

62
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

52
checked on Nov 14, 2017

Page view(s)

56
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.