Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.biomaterials.2008.01.024
DC Field | Value | |
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dc.title | Electrospun nanofiber scaffolds for rapid and rich capture of bone marrow-derived hematopoietic stem cells | |
dc.contributor.author | Ma, K. | |
dc.contributor.author | Chan, C.K. | |
dc.contributor.author | Liao, S. | |
dc.contributor.author | Hwang, W.Y.K. | |
dc.contributor.author | Feng, Q. | |
dc.contributor.author | Ramakrishna, S. | |
dc.date.accessioned | 2014-06-17T06:19:51Z | |
dc.date.available | 2014-06-17T06:19:51Z | |
dc.date.issued | 2008-05 | |
dc.identifier.citation | Ma, K., Chan, C.K., Liao, S., Hwang, W.Y.K., Feng, Q., Ramakrishna, S. (2008-05). Electrospun nanofiber scaffolds for rapid and rich capture of bone marrow-derived hematopoietic stem cells. Biomaterials 29 (13) : 2096-2103. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2008.01.024 | |
dc.identifier.issn | 01429612 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/60151 | |
dc.description.abstract | Interactions between bone marrow-derived hematopoietic stem cells (BM-HSCs) and their local microenvironment are an integral part of signaling control of BM-HSCs migration, proliferation and differentiation. We hypothesized that both substrate topographical and biochemical cues promote BM-HSCs adhesive behaviors, which are crucial for BM-HSCs' homing, self-renewal and lineage commitment within their microenvironment. We employed electrospinning technique to fabricate nanofiber scaffolds (NFS) with poly(dl-lactide-co-glycolide) blended with collagen I. NFS was further coated with E-selectin, a critical adhesive biomolecule. Capture efficiency study showed that blended NFS, after coated with E-selectin, significantly increased cell capture percentage from 23.40% to 67.41% within 30 min and from 29.44% to 70.19% within 60 min of incubation at room temperature. This study highlights the potential of using a biomimetic scaffold to design a site-specific niche-like unit for facilitating proliferation or differentiation functions of BM-HSCs. © 2008 Elsevier Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2008.01.024 | |
dc.source | Scopus | |
dc.subject | Cell adhesion | |
dc.subject | Electrospinning | |
dc.subject | Hematopoietic stem cells | |
dc.subject | Nanofiber | |
dc.type | Article | |
dc.contributor.department | BIOENGINEERING | |
dc.contributor.department | ORTHOPAEDIC SURGERY | |
dc.contributor.department | MECHANICAL ENGINEERING | |
dc.description.doi | 10.1016/j.biomaterials.2008.01.024 | |
dc.description.sourcetitle | Biomaterials | |
dc.description.volume | 29 | |
dc.description.issue | 13 | |
dc.description.page | 2096-2103 | |
dc.description.coden | BIMAD | |
dc.identifier.isiut | 000256853100010 | |
Appears in Collections: | Staff Publications |
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