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Title: Effect of pain perception on the heartbeat evoked potential
Authors: Shao, S. 
Shen, K. 
Wilder-Smith, E.P.V.
Li, X. 
Keywords: Alternative pain measure
Heartbeat evoked potential
Interoceptive process
Pain perception
Issue Date: Sep-2011
Citation: Shao, S., Shen, K., Wilder-Smith, E.P.V., Li, X. (2011-09). Effect of pain perception on the heartbeat evoked potential. Clinical Neurophysiology 122 (9) : 1838-1845. ScholarBank@NUS Repository.
Abstract: Objective: To investigate the effect of acute tonic pain on the heartbeat-evoked potential (HEP) and to test whether or not pain perception can be reflected by the HEP. Methods: Simultaneous electroencephalogram (EEG) and electrocardiogram (ECG) were recorded from 21 healthy young adults in three conditions: passive no-task control, no-pain control and cold pain. The HEP was obtained by using ECG R-peaks as event triggers. Results: Prominent HEP deflection was observed in both control conditions mainly over the frontal and central locations, while it was significantly suppressed in the cold pain condition over the right-frontal, right-central and midline locations. A comparison of the data in the first and last 5. min of cold pain condition showed that lower subjective pain ratings were accompanied by higher HEP magnitudes. A correlation analysis showed that the mean HEP magnitude over the midline locations was significantly negatively correlated with subjective pain ratings. Conclusions: Cold pain induces significant suppression of the HEP across a number of scalp locations, and the suppression is correlated with self-report of pain. Significance: The HEP has the potential to serve as an alternative pain measure. © 2011 International Federation of Clinical Neurophysiology.
Source Title: Clinical Neurophysiology
ISSN: 13882457
DOI: 10.1016/j.clinph.2011.02.014
Appears in Collections:Staff Publications

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