Please use this identifier to cite or link to this item: https://doi.org/10.1163/1568562042459733
Title: Characterization of neural stem cells on electrospun poly(L-lactic acid) nanofibrous scaffold
Authors: Yang, F.
Xu, C.Y. 
Kotaki, M. 
Wang, S.
Ramakrishna, S. 
Keywords: Electrospinning
Nanofibers
Neural stem cell
Neural tissue engineering
Poly(L-lactic acid)
Porosity
Scaffold
Issue Date: 2004
Source: Yang, F., Xu, C.Y., Kotaki, M., Wang, S., Ramakrishna, S. (2004). Characterization of neural stem cells on electrospun poly(L-lactic acid) nanofibrous scaffold. Journal of Biomaterials Science, Polymer Edition 15 (12) : 1483-1497. ScholarBank@NUS Repository. https://doi.org/10.1163/1568562042459733
Abstract: Nanofibrous poly(L-lactic acid) (PLLA) scaffolds were fabricated by an electrospinning technique and characterized by scanning electron microscopy, mercury porosimeter, atomic force microscopy and contact-angle test, The produced PLLA fibers with diameters ranging from 150 to 350 nm were randomly orientated with interconnected pores varying from several μm to about 140 μm in-between to form a three-dimensional architecture, which resembles the natural extracellular matrix structure in human body. The in vitro cell culture study was performed and the results indicate that the nanofibrous scaffold not only supports neural stem cell (NSC) differentiation and neurites out-growth, but also promotes NSC adhesion. The favorable interaction between the NSCs and the nanotibrous scaffold may be due to the greatly improved surface roughness of the electrospun nanofibrous scaffold. As evidenced by this study, the electrospun nanofibrous scaffold is expected to play a significant role in neural tissue engineering. © VSP 2004.
Source Title: Journal of Biomaterials Science, Polymer Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/59699
ISSN: 09205063
DOI: 10.1163/1568562042459733
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