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|Title:||Hybrid biomaterials based on the interaction of polyurethane oligomers with porcine pericardium|
Porcine pericardium fixation
|Citation:||Loke, W.K., Khor, E., Wee, A., Teoh, S.H., Chian, K.S. (1996-11). Hybrid biomaterials based on the interaction of polyurethane oligomers with porcine pericardium. Biomaterials 17 (22) : 2163-2172. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(96)00053-1|
|Abstract:||Hybrid biomaterials have been produced by the interaction of polyurethane oligomers with both fresh and glutaraldehyde-fixed porcine pericardium. The hybrid biomaterials so formed were translucent with occasional white streaks and/or spots, had increased stiffness (to touch) but remained pliable. No shrinkage temperature was detected for fresh porcine pericardium hybrid up to 100°C compared to porcine pericardium (~67°C) and glutaraldehyde-fixed porcine pericardium (~87°C). Amino acid analysis of the fresh porcine pericardium hybrid showed a reduction in lysine content after active isocyanate-terminated polyurethane oligomers exposure, indicating cross-linking between the polymer and tissue. Histological examination of the hybrid material shows a thin grey coating on both surfaces of the tissue, implying at least surface cross-linking of the tissue with polyurethane. The results suggest that fresh porcine pericardium can be reacted with active isocyanate-terminated polyurethane oligomers to produce hybrid biomaterials with covalent bonding.|
|Appears in Collections:||Staff Publications|
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