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Title: Hybrid biomaterials based on the interaction of polyurethane oligomers with porcine pericardium
Authors: Loke, W.K.
Khor, E. 
Wee, A.
Teoh, S.H. 
Chian, K.S.
Keywords: Bioprostheses
Hybrid biomaterial
Polyurethane oligomers
Porcine pericardium fixation
Issue Date: Nov-1996
Citation: Loke, W.K., Khor, E., Wee, A., Teoh, S.H., Chian, K.S. (1996-11). Hybrid biomaterials based on the interaction of polyurethane oligomers with porcine pericardium. Biomaterials 17 (22) : 2163-2172. ScholarBank@NUS Repository.
Abstract: Hybrid biomaterials have been produced by the interaction of polyurethane oligomers with both fresh and glutaraldehyde-fixed porcine pericardium. The hybrid biomaterials so formed were translucent with occasional white streaks and/or spots, had increased stiffness (to touch) but remained pliable. No shrinkage temperature was detected for fresh porcine pericardium hybrid up to 100°C compared to porcine pericardium (~67°C) and glutaraldehyde-fixed porcine pericardium (~87°C). Amino acid analysis of the fresh porcine pericardium hybrid showed a reduction in lysine content after active isocyanate-terminated polyurethane oligomers exposure, indicating cross-linking between the polymer and tissue. Histological examination of the hybrid material shows a thin grey coating on both surfaces of the tissue, implying at least surface cross-linking of the tissue with polyurethane. The results suggest that fresh porcine pericardium can be reacted with active isocyanate-terminated polyurethane oligomers to produce hybrid biomaterials with covalent bonding.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/0142-9612(96)00053-1
Appears in Collections:Staff Publications

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