Please use this identifier to cite or link to this item: https://doi.org/10.1002/rcs.239
Title: Robust computer-controlled system for intracytoplasmic sperm injection and subsequent cell electro-activation
Authors: Tan, K.K. 
Huang, S. 
Tang, K.Z. 
Keywords: Intracytoplasmic sperm injection cell electro-activation computer-controlled system
Issue Date: 2009
Source: Tan, K.K., Huang, S., Tang, K.Z. (2009). Robust computer-controlled system for intracytoplasmic sperm injection and subsequent cell electro-activation. International Journal of Medical Robotics and Computer Assisted Surgery 5 (1) : 85-98. ScholarBank@NUS Repository. https://doi.org/10.1002/rcs.239
Abstract: Introduction: Intracytoplasmic sperm injection (ICSI) and the subsequent cell electro-activation process is a relatively new enhanced procedure to address male factor infertility. The current method involves the engagement of experienced embryologists for such a purpose. More advanced methodologies, which use high precision instrumentation tools, will speed up the whole procedure. Methods: In this paper, the development of a computer-controlled system for ICSI and the subsequent cell electro-activation process is presented. The system is integrated to a microinjection workstation and piezo-actuator to perform the ICSI procedure, with vision capability to automatically position the components precisely. A micro-pump assembly is utilized for automatic medium refreshment and a heater plate assembly provides temperature control during the cell electro-activation process. The overall system is comprehensive, comprising modular functional components integrated within a hardware architecture. Results: Experimental results on mice oocytes verified the effectiveness of the developed system over the current method. Conclusions: Further improvements on the instrumentation tools will improve the robustness and overall performance of the developed system. Copyright © 2009 John Wiley & Sons, Ltd.
Source Title: International Journal of Medical Robotics and Computer Assisted Surgery
URI: http://scholarbank.nus.edu.sg/handle/10635/57295
ISSN: 14785951
DOI: 10.1002/rcs.239
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