Please use this identifier to cite or link to this item: https://doi.org/10.1063/1.3040313
Title: Biomicrofluidic lab-on-chip device for cancer cell detection
Authors: He, J.H.
Reboud, J.
Ji, H.
Zhang, L.
Long, Y.
Lee, C. 
Issue Date: 2008
Source: He, J.H., Reboud, J., Ji, H., Zhang, L., Long, Y., Lee, C. (2008). Biomicrofluidic lab-on-chip device for cancer cell detection. Applied Physics Letters 93 (22) : -. ScholarBank@NUS Repository. https://doi.org/10.1063/1.3040313
Abstract: A lab-on-a-chip microfluidic device was designed, fabricated, and tested to be used in cancer cell or disease cell detection in body fluids. Mixtures of breast cancer cells MCF-7 and control cells MCF-10A were captured by meandering weir filters in microfluidic channels. A selective fluorescent complex 17Β -estradiol-bovine serum albumin-fluorescein isothiocyanate enabled to specifically detect MCF-7 after only 4 min of contact. These signals are about seven times stronger than that of a labeling performed on conventional glass slides following the same protocol. The simple method could have the potential to replace complex existing cancer or disease detection schemes. © 2008 American Institute of Physics.
Source Title: Applied Physics Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/55206
ISSN: 00036951
DOI: 10.1063/1.3040313
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